T. Cruzi O-glycans

Synthetic O-Glycan Standards

As part of an NIH Common Fund grant (R21AI123161), several T. cruzi derived O-glycans were acquired and are available in 25 ug aliquots to the research community.

Available Glycans

1. Galpβ1,2Galpβ1,6(U-13C-Galpβ1,4)GlcNAcitol              TET-023
2. Galpβ1,2Galpβ1,6(U-13C-Galpβ1,3)GlcNAcitol              TET-024
3. Galpβ1,2Galpβ1,6(U-13C-Galfβ1,4)GlcNAcitol               TET-025
4. Galpβ1,3Galpβ1,6(U-13C-Galfβ1,4)GlcNAcitol               TET-026
5. Galpα1,3[U-13C]Galpβ1,4)GlcNAcitol                                   TRI-023

Glycan Standard Characteristics

These synthetic glycans are based on T. cruzi O-glycans.  Note that 4 of the 5 (A-D) standards are isomeric compounds differing only in linkage or cyclic ring forms present.  Thus, these standards are highly useful for optimizing separation and assignment platforms.  All 5 standards have been verified by both LC-MSn and 2D-NMR techniques and purity is in excess of 98% for all 5 standards.

For further information about synthetic standards, please contact:

Dr. Chris West
The University of Georgia,
Athens, Georgia 30602-4712, USA
Tel.: 706-542-4259
Email:westcm@uga.edu

Other services of the CCRC. The CCRC offers routine composition and sequence analysis of complex carbohydrates of plant, microbe, or animal origin. Specialized mass spectrometric and NMR spectroscopic analyses can also be performed, as can computer modeling of small and large molecules, and even of receptors and their ligands. The expertise of the CCRC faculty is wide-ranging and, as a result, we can provide comprehensive services for multifaceted projects. [Please take a look at our Web page (www.ccrc.uga.edu) for further general information about the full range of our services.]