We are excited to share a recent podcast on our research on glycosylation of key coronavirus protein (Spike) and its receptor, and its relevance to facilitate the development of effective vaccine against #COVID19 pandemic. Read more →
The Analytical Services and Training at the Complex Carbohydrate Research Center (AST-CCRC) provides services in the isolation, structural elucidation and validation of polysaccharides, glycoproteins, and glycolipids. These services are offered to university, government, and industrial laboratories world-wide.
We offer: In-depth structural characterization of samples derived from plant, animal, bacteria, or produced through cell culture. The Analytical Services team has the expertise and experience to tackle the most challenging projects in the analysis of glycoconjugates. Each year, CCRC Analytical Services and Training provides specialized carbohydrate analyses to over 100 clients. Although we are not GLP-certified, we are committed to follow the GLP and GMP regulation and ICH guidelines. We also develop and perform method validations. The CCRC is willing to sign confidential disclosure agreements with companies and universities upon request.
Hands-on training: Analytical Services and Training offers Glycobiology courses for scientists every summer in academic, governmental and industry. We train undergraduate and graduate students, postdoctoral research associates, and visiting scientists from the United States and around the world in the principles, methods, and analytical techniques used to study complex carbohydrates. In addition to offering carbohydrate analytical services and training to the scientific community, the AST- CCRC also conducts research into new methods for glycoscience research.
About the CCRC: The CCRC was founded at the University of Georgia in September 1985 to answer the national need for a center devoted to increasing knowledge of the structures and functions of complex carbohydrates. Evidence was rapidly growing of the key roles these molecules play in a broad range of biological recognition and regulatory phenomena — cellular communication, gene expression, immunology, organism defense mechanisms, growth and development. As this area of research had been a relatively under-funded and under-staffed endeavor in the United States, it was essential to direct more research attention and investment toward elucidating the chemical structures and biological functions of the oligo- and polysaccharides involved in these processes, to train more glycoscientists, and to bring together the multidisciplinary expertise and the expensive instrumentation required to serve the scientific community.
Today, the CCRC is home to three federally designated centers for carbohydrate research: the Department of Energy (DOE)-funded Center for Plant and Microbial Complex Carbohydrates, the National Institutes of Health (NIH)/ NCRR Research Resource for Integrated Glycotechnology and the NIH/NCRR Integrated Technology Resource for Biomedical Glycomics. Analytical Services and Training at the CCRC are committed to facilitating glycobiology and glycoscience research and training.
Comprehensive characterization of N-and O-glycosylation of SARS-CoV-2 human receptor angiotensin converting enzyme 2(2020)
Shajahan A, Archer-Hartmann SA, Supekar NT, Gleinich AS, Heiss C, Azadi P
Read Full Article: http://doi.org/10.1101/2020.05.01.071688
Deducing the N-and O-glycosylation profile of the spike protein of novel coronavirus SARS-CoV-2(2020)
Shajahan A, Supekar NT, Gleinich AS, Azadi P
Read Full Article:http://doi.org/10.1101/2020.04.01.020966
Simplifying Glycan Profiling through a High-Throughput Micropermethylation Strategy(2020)
Shajahan A, Supekar NT, Chapla D, Heiss C, Moremen KW, Azadi P
Read Full Article: http://doi.org/10.1177/2472630320912929
New strategies for profiling and characterization of human milk oligosaccharides(2020)
Porfirio S, Archer-Hartmann SA, Moreau GB, Ramakrishnan G, Haque R, Kirkpatrick BD, Petri WA, Azadi P
Read Full Article: http://doi.org/10.1093/glycob/cwaa028
Exploring the scope of high throughput micro‐permethylation based glycomics(2020)
Shajahan A, Supekar NT, Heiss C, Azadi P
Read Full Article: http://doi.org/10.1096/fasebj.2020.34.s1.06510
Binding of phage-encoded FlaGrab to motile Campylobacter jejuni flagella inhibits growth, downregulates energy metabolism, and requires specific flagellar glycans(2020)
Sacher JC, Shajahan A, Butcher J, Patry RT, Flint A, Hendrixson DR, Stintzi A, Azadi P, Szymanski CM
Read Full Article: http://doi.org/10.3389/fmicb.2020.00397
Mass spectrometric method for the unambiguous profiling of cellular dynamic glycosylation(2020)
Shajahan A, Supekar NT, Wu H, Wands AM, Bhat G, Kalimurthy A, Matsubara M, Ranzinger R, Kohler JJ, Azadi P
Read Full Article:http://doi.org/10.1101/2020.05.04.075655
Species-specific recognition of Sulfolobales mediated by UV-inducible pili and S-layer glycosylation patterns(2020)
Wolferen M van, Shajahan A, Heinrich K, Brenzinger S, Black IM, Wagner A, Briegel A, Azadi P, Albers SV
Read Full Article: http://doi.org/10.1128/mBio.03014-19