Collaboration

A major goal of the Analytical Services laboratory at the Complex Carbohydrate Research Center is to stimulate collaboration with members of the broader scientific community. In addition to standard service projects, the Analytical Services laboratory also routinely works with various organizations in the form of research collaborations. This work serves to strengthen the current field of carbohydrate research, as well as to provide the feedback necessary to refine current technology and identify new needs in the field.

Collaboration projects involve our expertise in the fields of plant and microbial polysaccharides, glycomics, glycoproteomics and proteoglycans. These collaborations commonly exploit still-emerging technologies where the projects can be more open-ended and generally require a greater interaction between personnel at the CCRC and outside investigators.

Dr. Parastoo Azadi is the coordinator of Collaborative Endeavors within the CCRC Analytical Services Group. With more than 25 years of experience in the field of polysaccharide and glycoprotein structural analysis, she is well equipped to assist investigators in the development of new collaborative projects with the scientific staff at the CCRC. Initial contact may be made directly with Dr. Azadi at azadi@uga.edu.

Publications resulting from these projects will very likely be co-authored by all those involved in the collaboration, and any publication using data from the Resource should include an acknowledgment similar to:

Plant and Microbial Polysaccharide Research

Should any of these data be used in a publication, please include the following statement in the acknowledgment: This work was supported by the Chemical Sciences, Geosciences and Biosciences Division, Office of Basic Energy Sciences, U.S. Department of Energy grant (DE-SC0015662) at the Complex Carbohydrate Research Center.

Biomedical Research

The R24 grant number R24GM137782 should be acknowledged in all publications, presentations, websites, press releases, etc., generated or resulting from research or services that has been performed through the CCRC Service and training laboratory. We ask that if our scientists contribute to intellectual aspect of the project or and the manuscript preparation, they be considered as co-authors on the publication as well: The carbohydrate analysis performed at the CCRC was supported by NIH R24GM137782 grant.

Recent Publications

Li H, Chapla D, Amos RA, Ramiah A, Moremen KW, Li H. Structural basis for heparan sulfate co-polymerase action by the EXT1-2 complex. Nat Chem Biol. 2023 May;19(5):565-574. doi: 10.1038/s41589-022-01220-2. Epub 2023 Jan 2. PMID: 36593275; PMCID: PMC10160006.

Andresen S, de Mojana di Cologna N, Archer-Hartmann S, Rogers AM, Samaddar S, Ganguly T, Black IM, Glushka J, Ng KKS, Azadi P, Lemos JA, Abranches J, Szymanski CM. Involvement of the Streptococcus mutans PgfE and GalE 4-epimerases in protein glycosylation, carbon metabolism, and cell division. Glycobiology. 2023 Apr 19;33(3):245-259. doi: 10.1093/glycob/cwad004. PMID: 36637425; PMCID: PMC10114643.

Hall MK, Shajahan A, Burch AP, Hatchett CJ, Azadi P, Schwalbe RA. Limited N-Glycan Processing Impacts Chaperone Expression Patterns, Cell Growth and Cell Invasiveness in Neuroblastoma. Biology (Basel). 2023 Feb 11;12(2):293. doi: 10.3390/biology12020293. PMID: 36829569; PMCID: PMC9953357.

Ahmed HA, Ticar BF, Black I, Mahdi F, Shami AA, Misra SK, Heiss C, Paris JJ, Sharp JS, Azadi P, Pomin VH. Structural characterization and biological activity of an α-glucan from the mollusk Marcia hiantina (Lamarck, 1818). Glycoconj J. 2023 Feb;40(1):33-46. doi: 10.1007/s10719-022-10092-6. Epub 2022 Dec 1. PMID: 36454453; PMCID: PMC9931679.

Zhan J, Lin D, Watson N, Esser L, Tang WK, Zhang A, Liu X, Hassan R, Gleinich A, Shajahan A, Azadi P, Pastan I, Xia D. Structures of Cancer Antigen Mesothelin and Its Complexes with Therapeutic Antibodies. Cancer Res Commun. 2023 Feb 1;3(2):175-191. doi: 10.1158/2767-9764.CRC-22-0306. PMID: 36968141; PMCID: PMC10035497.