Capillary Electrophoresis (CE) is a family of separations techniques that resolves analytes based on their charge-to-size ratio. Capillary electrophoresis and Capillary Gel Electrophoresis are frequently used methodologies in carbohydrate separations for their superior separation efficiencies and quick analysis times.
- Additionally CE is a high-throughput, low sample consumption methodology that is well suited for quality assurance, characterization, and fingerprinting studies.
- With the application of fluorescent labeled to a glycan or oligosaccharide’s reducing end, CE-based separations can be used for quantification, as well as for very low limits of detection.
- The CCRC Analytical Services Laboratory has a Beckman Coulter PA800 Pharmaceutical Analysis System that may be coupled with UV, PDA, or Fluorescence Detection modules. Also, our laboratory has a Beckman Coulter CESI 8000, the first commercially available system designed to couple CE separations to mass spectrometry.