Collaboration
A major goal of the Analytical Services laboratory at the Complex Carbohydrate Research Center is to stimulate collaboration with members of the broader scientific community. In addition to standard service projects, the Analytical Services laboratory also routinely works with various organizations in the form of research collaborations. This work serves to strengthen the current field of carbohydrate research, as well as to provide the feedback necessary to refine current technology and identify new needs in the field.
Collaboration projects involve our expertise in the fields of plant and microbial polysaccharides, glycomics, glycoproteomics and proteoglycans. These collaborations commonly exploit still-emerging technologies where the projects can be more open-ended and generally require a greater interaction between personnel at the CCRC and outside investigators.
Dr. Parastoo Azadi is the coordinator of Collaborative Endeavors within the CCRC Analytical Services Group. With more than 30 years of experience in the field of polysaccharide and glycoprotein structural analysis, she is well equipped to assist investigators in the development of new collaborative projects with the scientific staff at the CCRC. Initial contact may be made directly with Dr. Azadi at azadi@uga.edu.
Publications resulting from these projects will very likely be co-authored by all those involved in the collaboration, and any publication using data from the Resource should include an acknowledgment similar to:
Plant and Microbial Polysaccharide Research
Should any of these data be used in a publication, please include the following statement in the acknowledgment: This work was supported by the Chemical Sciences, Geosciences and Biosciences Division, Office of Basic Energy Sciences, U.S. Department of Energy grant (DE-SC0015662) at the Complex Carbohydrate Research Center.
Biomedical Research
The R24 grant number R24GM137782 should be acknowledged in all publications, presentations, websites, press releases, etc., generated or resulting from research or services that has been performed through the CCRC Service and training laboratory. We ask that if our scientists contribute to intellectual aspect of the project or and the manuscript preparation, they be considered as co-authors on the publication as well: The carbohydrate analysis performed at the CCRC was supported by NIH R24GM137782 grant.
Recent Publications
Skeeters S, Bagale K, Stepanyuk G, Thieker D, Aguhob A, Chan KK, Dutzar B, Shalygin S, Shajahan A, Yang X, DaRosa PA, Frazier E, Sauer MM, Bogatzki L, Byrnes-Blake KA, Song Y, Azadi P, Tarcha E, Zhang L, Procko E. Modulation of the pharmacokinetics of soluble ACE2 decoy receptors through glycosylation. Mol Ther Methods Clin Dev. 2024 Jul 19;32(3):101301. DOI: 10.1016/j.omtm.2024.101301. PMID: 39185275; PMCID: PMC11342882.
Menghwar H, Tatum FM, Briggs RE, Kanipe C, Casas E, Kaptur J, Kaplan BS, Inzana TJ, Azadi P, Dassanayake RP. Characterization of Histophilus somni sialic acid uptake mutant (ΔnanP-ΔnanU) using a mouse septicemia and mortality model. Microb Pathog. 2024 Sep;194:106839. DOI: 10.1016/j.micpath.2024.106839. Epub 2024 Aug 3. PMID: 39103126.
Song Y, Singh A, Feroz MM, Xu S, Zhang F, Jin W, Kumar A, Azadi P, Metzger DW, Linhardt RJ, Dordick JS. Seaweed-derived fucoidans and rhamnan sulfates serve as potent anti-SARS-CoV-2 agents with potential for prophylaxis. Carbohydr Polym. 2024 Aug 1;337:122156. DOI: 1016/j.carbpol.2024.122156 Epub 2024 Apr 16. PMID: 38710572.
Chatrath A, Dey P, Greeley K, Maciel G, Huang L, Heiss C, Black I, Azadi P, Free SJ. Characterization of the Neurospora crassa Galactosaminogalactan Biosynthetic Pathway. Microorganisms. 2024 Jul 23;12(8):1509. doi: 10.3390/microorganisms12081509. PMID: 39203353; PMCID: PMC11356417.
Goetsch AG, Ufearo D, Keiser G, Heiss C, Azadi P, Hershey DM. An exopolysaccharide pathway from a freshwater Sphingomonas isolate. J Bacteriol. 2024 Aug 22;206(8):e0016924. DOI: 10.1128/jb.00169-24. Epub 2024 Jul 15. PMID: 39007563; PMCID: PMC11340318.
Wightman T, Muszyński A, Kelly SJ, Sullivan JT, Smart CJ, Stougaard J, Ferguson S, Azadi P, Ronson CW. Rhizobial secretion of truncated exopolysaccharides severely impairs the Mesorhizobium-Lotus symbiosis. Mol Plant Microbe Interact. 2024 Jun 21. DOI: 10.1094/MPMI-03-24-0024-R. Epub ahead of print. PMID: 38904752.
Backman T, Latorre SM, Symeonidi E, Muszyński A, Bleak E, Eads L, Martinez-Koury PI, Som S, Hawks A, Gloss AD, Belnap DM, Manuel AM, Deutschbauer AM, Bergelson J, Azadi P, Burbano HA, Karasov TL. A phage tail-like bacteriocin suppresses competitors in metapopulations of pathogenic bacteria. Science. 2024 Jun 14;384(6701):eado0713. DOI: 10.1126/science.ado0713. Epub 2024 Jun 14. PMID: 38870284.
Ghods S, Muszyński A, Yang H, Seelan RS, Mohammadi A, Hilson JS, Keiser G, Nichols FC, Azadi P, Ernst RK, Moradali F. The multifaceted role of c-di-AMP signaling in the regulation of Porphyromonas gingivalis lipopolysaccharide structure and function. Front Cell Infect Microbiol. 2024 Jun 12;14:1418651. DOI: 10.3389/fcimb.2024.1418651. PMID: 38933693; PMCID: PMC11199400.
Lei MG, Jorgenson MA, Robbs EJ, Black IM, Archer-Hartmann S, Shalygin S, Azadi P, Lee CY. Characterization of Ssc, an N-acetylgalactosamine-containing surface polysaccharide. J Bacteriol. 2024 May 23;206(5):e0004824. DOI: 1128/jb.00048-24 Epub 2024 May 7. PMID: 38712944; PMCID: PMC11112989.
Ndukwe IE, Black I, Castro CA, Vlach J, Heiss C, Roper C, Azadi P. Permethylation as a strategy for high-molecular-weight polysaccharide structure analysis by nuclear magnetic resonance-Case study of Xylella fastidiosa extracellular polysaccharide. Magn Reson Chem. 2024 May;62(5):370-377. DOI: 10.1002/mrc.5413 Epub 2023 Nov 20. PMID: 37985228; PMCID: PMC11047163.
Tan L, Cheng J, Zhang L, Backe J, Urbanowicz B, Heiss C, Azadi P. Pectic-AGP is a major form of Arabidopsis AGPs. Carbohydr Polym. 2024 Apr 15;330:121838. DOI: 10.1016/j.carbpol.2024.121838 Epub 2024 Jan 20. PMID: 38368088.